toll-like receptor 2

Symbol

TLR2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Toll-9 Drosophila melanogaster
tlr2 Danio rerio
Tlr2 Mus musculus
Tlr2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2223 toll-like receptor 2 increases with age Molecular parietal lobe Human TLR2 189.1% Increase Gene Expression Level
DAA2237 toll-like receptor 2 increases with age Molecular frontal lobe Human TLR2 155.6% Increase Gene Expression Level
DAA2205 toll-like receptor 2 increases with age Molecular temporal lobe Human TLR2 185.1% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002221 pattern recognition receptor signaling pathway biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006955 immune response biological_process
GO:0007165 signal transduction biological_process
GO:0007252 I-kappaB phosphorylation biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0030177 positive regulation of Wnt receptor signaling pathway biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032722 positive regulation of chemokine production biological_process
GO:0032728 positive regulation of interferon-beta production biological_process
GO:0032735 positive regulation of interleukin-12 production biological_process
GO:0032741 positive regulation of interleukin-18 production biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032757 positive regulation of interleukin-8 production biological_process
GO:0032760 positive regulation of tumor necrosis factor production biological_process
GO:0034123 positive regulation of toll-like receptor signaling pathway biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0042346 positive regulation of NF-kappaB import into nucleus biological_process
GO:0042495 detection of triacyl bacterial lipopeptide biological_process
GO:0042496 detection of diacyl bacterial lipopeptide biological_process
GO:0045087 innate immune response biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0050729 positive regulation of inflammatory response biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process biological_process
GO:0071221 cellular response to bacterial lipopeptide biological_process
GO:0071223 cellular response to lipoteichoic acid biological_process
GO:0071726 cellular response to diacyl bacterial lipopeptide biological_process
GO:0071727 cellular response to triacyl bacterial lipopeptide biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex cellular_component
GO:0001875 lipopolysaccharide receptor activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008329 pattern recognition receptor activity molecular_function
GO:0042497 triacyl lipopeptide binding molecular_function
GO:0042834 peptidoglycan binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0051637 Gram-positive bacterial cell surface binding molecular_function