transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Symbol

TAP2 (may also be known as: None)

Organism

Human

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3422 Gene expression of TAP2 increases with age Molecular skin Human TAP2 —

GO Terms

GO IDGO TermGO Category
GO:0001916 positive regulation of T cell mediated cytotoxicity biological_process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent biological_process
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent biological_process
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent biological_process
GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent biological_process
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II biological_process
GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0006955 immune response biological_process
GO:0015031 protein transport biological_process
GO:0015833 peptide transport biological_process
GO:0019060 intracellular transport of viral proteins in host cell biological_process
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I biological_process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0046967 cytosol to ER transport biological_process
GO:0046968 peptide antigen transport biological_process
GO:0055085 transmembrane transport biological_process
GO:0005634 nucleus cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0030670 phagocytic vesicle membrane cellular_component
GO:0042613 MHC class II protein complex cellular_component
GO:0042825 TAP complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005215 transporter activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0015197 peptide transporter activity molecular_function
GO:0015421 oligopeptide-transporting ATPase activity molecular_function
GO:0015433 peptide antigen-transporting ATPase activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0042288 MHC class I protein binding molecular_function
GO:0042605 peptide antigen binding molecular_function
GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function
GO:0046978 TAP1 binding molecular_function
GO:0046979 TAP2 binding molecular_function
GO:0046980 tapasin binding molecular_function