biotinidase

Symbol

BTD (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

Orthologs

SymbolSpecies
btd Danio rerio
Btd Mus musculus
Btd Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3015 Gene expression of BTD decreases with age Molecular skin Human BTD —

GO Terms

GO IDGO TermGO Category
GO:0006807 nitrogen compound metabolic process biological_process
GO:0007417 central nervous system development biological_process
GO:0008544 epidermis development biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005730 nucleolus cellular_component
GO:0043204 perikaryon cellular_component
GO:0045177 apical part of cell cellular_component
GO:0004075 biotin carboxylase activity molecular_function
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function
GO:0047708 biotinidase activity molecular_function