spectrin, beta, non-erythrocytic 1
Symbol
SPTBN1
(may also be known as: None)
Organism
Human
Description
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| sptbn2 | Danio rerio | |
| Sptbn1 | Mus musculus | |
| Sptbn1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007182 | common-partner SMAD protein phosphorylation | biological_process | |
| GO:0007184 | SMAD protein import into nucleus | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0051693 | actin filament capping | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0008091 | spectrin | cellular_component | |
| GO:0030863 | cortical cytoskeleton | cellular_component | |
| GO:0031430 | M band | cellular_component | |
| GO:0032437 | cuticular plate | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |
| GO:0005200 | structural constituent of cytoskeleton | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005516 | calmodulin binding | molecular_function | |