BCL2-related ovarian killer
Symbol
BOK
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| Buffy | Drosophila melanogaster | |
| boka | Danio rerio | |
| Bok | Mus musculus | |
| Bok | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006915 | apoptotic process | biological_process | |
| GO:0006917 | induction of apoptosis | biological_process | |
| GO:0006919 | activation of caspase activity | biological_process | |
| GO:0007420 | brain development | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0008584 | male gonad development | biological_process | |
| GO:0048709 | oligodendrocyte differentiation | biological_process | |
| GO:0072332 | signal transduction by p53 class mediator resulting in induction of apoptosis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0031966 | mitochondrial membrane | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0046982 | protein heterodimerization activity | molecular_function | |
| GO:0051400 | BH domain binding | molecular_function | |