sorbitol dehydrogenase

Symbol

SORD (may also be known as: None)

Organism

Human

Description

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

Orthologs

SymbolSpecies
CELE_R04B5.6 Caenorhabditis elegans
Sodh-2 Drosophila melanogaster
sord Danio rerio
Sord Mus musculus
LOC100911895 Rattus norvegicus
SOR2 Saccharomyces cerevisiae
tms1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3406 Gene expression of SORD decreases with age Molecular skin Human SORD —

GO Terms

GO IDGO TermGO Category
GO:0006006 glucose metabolic process biological_process
GO:0006062 sorbitol catabolic process biological_process
GO:0030317 sperm motility biological_process
GO:0046370 fructose biosynthetic process biological_process
GO:0051160 L-xylitol catabolic process biological_process
GO:0051164 L-xylitol metabolic process biological_process
GO:0005615 extracellular space cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005929 cilium cellular_component
GO:0016020 membrane cellular_component
GO:0019861 flagellum cellular_component
GO:0031966 mitochondrial membrane cellular_component
GO:0003939 L-iditol 2-dehydrogenase activity molecular_function
GO:0005529 sugar binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0051287 NAD binding molecular_function