superoxide dismutase 2, mitochondrial

Symbol

SOD2 (may also be known as: None)

Organism

Human

Description

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
sod-3 Caenorhabditis elegans
Sod2 Drosophila melanogaster
sod2 Danio rerio
Sod2 Mus musculus
Sod2 Rattus norvegicus
SOD2 Saccharomyces cerevisiae
SPBC16A3.14 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3405 Gene expression of SOD2 decreases with age Molecular skin Human SOD2 —

GO Terms

GO IDGO TermGO Category
GO:0000303 response to superoxide biological_process
GO:0001306 age-dependent response to oxidative stress biological_process
GO:0001315 age-dependent response to reactive oxygen species biological_process
GO:0001666 response to hypoxia biological_process
GO:0001836 release of cytochrome c from mitochondria biological_process
GO:0001889 liver development biological_process
GO:0003032 detection of oxygen biological_process
GO:0003069 vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure biological_process
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0006749 glutathione metabolic process biological_process
GO:0006801 superoxide metabolic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0007005 mitochondrion organization biological_process
GO:0007507 heart development biological_process
GO:0007568 aging biological_process
GO:0007626 locomotory behavior biological_process
GO:0008217 regulation of blood pressure biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009791 post-embryonic development biological_process
GO:0010042 response to manganese ion biological_process
GO:0010043 response to zinc ion biological_process
GO:0010269 response to selenium ion biological_process
GO:0010332 response to gamma radiation biological_process
GO:0014823 response to activity biological_process
GO:0019430 removal of superoxide radicals biological_process
GO:0022904 respiratory electron transport chain biological_process
GO:0030097 hemopoiesis biological_process
GO:0031667 response to nutrient levels biological_process
GO:0032364 oxygen homeostasis biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0033591 response to L-ascorbic acid biological_process
GO:0034021 response to silicon dioxide biological_process
GO:0042493 response to drug biological_process
GO:0042542 response to hydrogen peroxide biological_process
GO:0042554 superoxide anion generation biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043524 negative regulation of neuron apoptosis biological_process
GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process
GO:0045599 negative regulation of fat cell differentiation biological_process
GO:0046686 response to cadmium ion biological_process
GO:0048147 negative regulation of fibroblast proliferation biological_process
GO:0048666 neuron development biological_process
GO:0048678 response to axon injury biological_process
GO:0048773 erythrophore differentiation biological_process
GO:0050665 hydrogen peroxide biosynthetic process biological_process
GO:0050790 regulation of catalytic activity biological_process
GO:0051260 protein homooligomerization biological_process
GO:0051289 protein homotetramerization biological_process
GO:0051602 response to electrical stimulus biological_process
GO:0051881 regulation of mitochondrial membrane potential biological_process
GO:0055072 iron ion homeostasis biological_process
GO:0055093 response to hyperoxia biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0071361 cellular response to ethanol biological_process
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0042645 mitochondrial nucleoid cellular_component
GO:0003677 DNA binding molecular_function
GO:0004784 superoxide dismutase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0019825 oxygen binding molecular_function
GO:0030145 manganese ion binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0046872 metal ion binding molecular_function