piezo-type mechanosensitive ion channel component 2
Symbol
PIEZO2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| Piezo2 | Mus musculus | |
| Piezo2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2915 | Gene expression of PIEZO2 decreases with age | Molecular | adipose tissue | Human | PIEZO2 | — |
GO Terms
| GO ID | GO Term | GO Category |
|---|---|---|
| GO:0006811 | ion transport | biological_process |
| GO:0016020 | membrane | cellular_component |
| GO:0016021 | integral to membrane | cellular_component |
| GO:0005216 | ion channel activity | molecular_function |