S100 calcium binding protein A8
Symbol
S100A8
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| S100a8 | Mus musculus | |
| S100a8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2206 | S100 calcium binding protein A8 increases with age | Molecular | temporal lobe | Human | S100A8 | 530.6% Increase Gene Expression Level | |
| DAA2243 | S100 calcium binding protein A8 increases with age | Molecular | frontal lobe | Human | S100A8 | 921.4% Increase Gene Expression Level | |
| DAA2217 | S100 calcium binding protein A8 increases with age | Molecular | hippocampus | Human | S100A8 | 1115.4% Increase Gene Expression Level | |
| DAA2231 | S100 calcium binding protein A8 increases with age | Molecular | parietal lobe | Human | S100A8 | 1228.2% Increase Gene Expression Level |
Changes associated with the orthologs of this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA1341 | S100 calcium binding protein A8 (calgranulin A) | Molecular | hematological system | Mouse | S100a8 | 40.0% Decrease Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002526 | acute inflammatory response | biological_process | |
| GO:0002544 | chronic inflammatory response | biological_process | |
| GO:0006935 | chemotaxis | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0010043 | response to zinc ion | biological_process | |
| GO:0032496 | response to lipopolysaccharide | biological_process | |
| GO:0042060 | wound healing | biological_process | |
| GO:0045471 | response to ethanol | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005509 | calcium ion binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |