sortilin 1

Symbol

SORT1 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
sort1b Danio rerio
Sort1 Mus musculus
Sort1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3375 Gene expression of SORT1 decreases with age Molecular skin Human SORT1 —

GO Terms

GO IDGO TermGO Category
GO:0001503 ossification biological_process
GO:0006810 transport biological_process
GO:0006895 Golgi to endosome transport biological_process
GO:0006897 endocytosis biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007218 neuropeptide signaling pathway biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008333 endosome to lysosome transport biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0010468 regulation of gene expression biological_process
GO:0014902 myotube differentiation biological_process
GO:0016050 vesicle organization biological_process
GO:0030154 cell differentiation biological_process
GO:0032509 endosome transport via multivesicular body sorting pathway biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0046323 glucose import biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048227 plasma membrane to endosome transport biological_process
GO:0051005 negative regulation of lipoprotein lipase activity biological_process
GO:0005634 nucleus cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0005768 endosome cellular_component
GO:0005769 early endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005905 coated pit cellular_component
GO:0009986 cell surface cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016023 cytoplasmic membrane-bounded vesicle cellular_component
GO:0030136 clathrin-coated vesicle cellular_component
GO:0030140 trans-Golgi network transport vesicle cellular_component
GO:0030425 dendrite cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0032580 Golgi cisterna membrane cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0004872 receptor activity molecular_function
GO:0010465 nerve growth factor receptor activity molecular_function
GO:0019899 enzyme binding molecular_function
GO:0030379 neurotensin receptor activity, non-G-protein coupled molecular_function
GO:0048406 nerve growth factor binding molecular_function