receptor-like tyrosine kinase

Symbol

RYK (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Orthologs

SymbolSpecies
lin-18 Caenorhabditis elegans
drl Drosophila melanogaster
ryk Danio rerio
Ryk Mus musculus
Ryk Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3373 Gene expression of RYK increases with age Molecular skin Human RYK —

GO Terms

GO IDGO TermGO Category
GO:0006468 protein phosphorylation biological_process
GO:0007165 signal transduction biological_process
GO:0007411 axon guidance biological_process
GO:0016055 Wnt receptor signaling pathway biological_process
GO:0022038 corpus callosum development biological_process
GO:0030182 neuron differentiation biological_process
GO:0031175 neuron projection development biological_process
GO:0043410 positive regulation of MAPKKK cascade biological_process
GO:0048705 skeletal system morphogenesis biological_process
GO:0048843 negative regulation of axon extension involved in axon guidance biological_process
GO:0050919 negative chemotaxis biological_process
GO:0071679 commissural neuron axon guidance biological_process
GO:0005624 membrane fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0005109 frizzled binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0017147 Wnt-protein binding molecular_function