ribophorin I

Symbol

RPN1 (may also be known as: None)

Organism

Human

Description

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ribo-1 Caenorhabditis elegans
CG33303 Drosophila melanogaster
rpn1 Danio rerio
Rpn1 Mus musculus
Rpn1 Rattus norvegicus
OST1 Saccharomyces cerevisiae
ost1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3370 Gene expression of RPN1 decreases with age Molecular skin Human RPN1 —

GO Terms

GO IDGO TermGO Category
GO:0006412 translation biological_process
GO:0006464 protein modification process biological_process
GO:0006486 protein glycosylation biological_process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane biological_process
GO:0010467 gene expression biological_process
GO:0018279 protein N-linked glycosylation via asparagine biological_process
GO:0043687 post-translational protein modification biological_process
GO:0044267 cellular protein metabolic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0008250 oligosaccharyltransferase complex cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0019718 rough microsome cellular_component
GO:0042470 melanosome cellular_component
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity molecular_function
GO:0016740 transferase activity molecular_function