ret proto-oncogene

Symbol

RET (may also be known as: None)

Organism

Human

Description

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Ret Drosophila melanogaster
ret Danio rerio
Ret Mus musculus
Ret Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2827 Gene expression of RET decreases with age Molecular adipose tissue Human RET —

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0001657 ureteric bud development biological_process
GO:0001755 neural crest cell migration biological_process
GO:0001838 embryonic epithelial tube formation biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007156 homophilic cell adhesion biological_process
GO:0007158 neuron cell-cell adhesion biological_process
GO:0007165 signal transduction biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0007399 nervous system development biological_process
GO:0007497 posterior midgut development biological_process
GO:0010976 positive regulation of neuron projection development biological_process
GO:0030155 regulation of cell adhesion biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0033619 membrane protein proteolysis biological_process
GO:0033630 positive regulation of cell adhesion mediated by integrin biological_process
GO:0042551 neuron maturation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0048265 response to pain biological_process
GO:0048484 enteric nervous system development biological_process
GO:0061146 Peyer's patch morphogenesis biological_process
GO:0071300 cellular response to retinoic acid biological_process
GO:0072300 positive regulation of metanephric glomerulus development biological_process
GO:0097021 lymphocyte migration into lymphoid organs biological_process
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand biological_process
GO:0005768 endosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005509 calcium ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function