retinoblastoma binding protein 8

Symbol

RBBP8 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
rbbp8 Danio rerio
Rbbp8 Mus musculus
Rbbp8 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3359 Gene expression of RBBP8 increases with age Molecular skin Human RBBP8 —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001835 blastocyst hatching biological_process
GO:0006281 DNA repair biological_process
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0007126 meiosis biological_process
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing biological_process
GO:0005634 nucleus cellular_component
GO:0017053 transcriptional repressor complex cellular_component
GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity molecular_function
GO:0001103 RNA polymerase II repressing transcription factor binding molecular_function
GO:0001106 RNA polymerase II transcription corepressor activity molecular_function
GO:0003684 damaged DNA binding molecular_function
GO:0004519 endonuclease activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016787 hydrolase activity molecular_function