polymerase (DNA-directed), delta 4, accessory subunit

Symbol

POLD4 (may also be known as: None)

Organism

Human

Description

This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Orthologs

SymbolSpecies
si:dkey-28b4.7 Danio rerio
Pold4 Mus musculus
Pold4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2913 Gene expression of POLD4 decreases with age Molecular adipose tissue Human POLD4 —

GO Terms

GO IDGO TermGO Category
GO:0000084 S phase of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0000722 telomere maintenance via recombination biological_process
GO:0000723 telomere maintenance biological_process
GO:0001938 positive regulation of endothelial cell proliferation biological_process
GO:0006260 DNA replication biological_process
GO:0006271 DNA strand elongation involved in DNA replication biological_process
GO:0006281 DNA repair biological_process
GO:0006283 transcription-coupled nucleotide-excision repair biological_process
GO:0006284 base-excision repair biological_process
GO:0006289 nucleotide-excision repair biological_process
GO:0006297 nucleotide-excision repair, DNA gap filling biological_process
GO:0032201 telomere maintenance via semi-conservative replication biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0003887 DNA-directed DNA polymerase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0016779 nucleotidyltransferase activity molecular_function