spectrin, beta, non-erythrocytic 4
Symbol
SPTBN4
(may also be known as: None)
Organism
Human
Description
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Sptbn4 | Mus musculus | |
| Sptbn4 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007016 | cytoskeletal anchoring at plasma membrane | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0007605 | sensory perception of sound | biological_process | |
| GO:0007628 | adult walking behavior | biological_process | |
| GO:0009566 | fertilization | biological_process | |
| GO:0016192 | vesicle-mediated transport | biological_process | |
| GO:0019226 | transmission of nerve impulse | biological_process | |
| GO:0030534 | adult behavior | biological_process | |
| GO:0040018 | positive regulation of multicellular organism growth | biological_process | |
| GO:0051693 | actin filament capping | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0005938 | cell cortex | cellular_component | |
| GO:0008091 | spectrin | cellular_component | |
| GO:0016363 | nuclear matrix | cellular_component | |
| GO:0016605 | PML body | cellular_component | |
| GO:0030424 | axon | cellular_component | |
| GO:0043203 | axon hillock | cellular_component | |
| GO:0070852 | cell body fiber | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |
| GO:0005200 | structural constituent of cytoskeleton | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0030506 | ankyrin binding | molecular_function | |