CDC-like kinase 4
Symbol
CLK4
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Clk4 | Mus musculus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0018108 | peptidyl-tyrosine phosphorylation | biological_process | |
| GO:0043484 | regulation of RNA splicing | biological_process | |
| GO:0046777 | protein autophosphorylation | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004674 | protein serine/threonine kinase activity | molecular_function | |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | molecular_function | |
| GO:0004713 | protein tyrosine kinase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | molecular_function | |