VANGL planar cell polarity protein 2

Symbol

VANGL2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Orthologs

SymbolSpecies
vang-1 Caenorhabditis elegans
Vang Drosophila melanogaster
vangl2 Danio rerio
Vangl2 Mus musculus
Vangl2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4013 Gene expression of VANGL2 increases with age Molecular skin Human VANGL2 —

GO Terms

GO IDGO TermGO Category
GO:0001736 establishment of planar polarity biological_process
GO:0001843 neural tube closure biological_process
GO:0001942 hair follicle development biological_process
GO:0001947 heart looping biological_process
GO:0003149 membranous septum morphogenesis biological_process
GO:0003150 muscular septum morphogenesis biological_process
GO:0003402 planar cell polarity pathway involved in axis elongation biological_process
GO:0007266 Rho protein signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0022007 convergent extension involved in neural plate elongation biological_process
GO:0032956 regulation of actin cytoskeleton organization biological_process
GO:0035019 somatic stem cell maintenance biological_process
GO:0035058 nonmotile primary cilium assembly biological_process
GO:0035787 cell migration involved in kidney development biological_process
GO:0042060 wound healing biological_process
GO:0045176 apical protein localization biological_process
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity biological_process
GO:0048103 somatic stem cell division biological_process
GO:0048105 establishment of body hair planar orientation biological_process
GO:0048546 digestive tract morphogenesis biological_process
GO:0060028 convergent extension involved in axis elongation biological_process
GO:0060122 inner ear receptor stereocilium organization biological_process
GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis biological_process
GO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis biological_process
GO:0060490 lateral sprouting involved in lung morphogenesis biological_process
GO:0090103 cochlea morphogenesis biological_process
GO:0090177 establishment of planar polarity involved in neural tube closure biological_process
GO:0090179 planar cell polarity pathway involved in neural tube closure biological_process
GO:0005886 plasma membrane cellular_component
GO:0005911 cell-cell junction cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0016328 lateral plasma membrane cellular_component
GO:0060187 cell pole cellular_component