proteasome (prosome, macropain) 26S subunit, ATPase, 5

Symbol

PSMC5 (may also be known as: None)

Organism

Human

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Orthologs

SymbolSpecies
CELE_F56F11.4 Caenorhabditis elegans
Pros45 Drosophila melanogaster
psmc5 Danio rerio
Psmc5 Mus musculus
Psmc5 Rattus norvegicus
RPT6 Saccharomyces cerevisiae
let1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3349 Gene expression of PSMC5 increases with age Molecular skin Human PSMC5 —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0000084 S phase of mitotic cell cycle biological_process
GO:0000209 protein polyubiquitination biological_process
GO:0000216 M/G1 transition of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent biological_process
GO:0006200 ATP catabolic process biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006508 proteolysis biological_process
GO:0006521 regulation of cellular amino acid metabolic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest biological_process
GO:0010467 gene expression biological_process
GO:0016032 viral reproduction biological_process
GO:0016070 RNA metabolic process biological_process
GO:0016071 mRNA metabolic process biological_process
GO:0030163 protein catabolic process biological_process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043069 negative regulation of programmed cell death biological_process
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0000502 proteasome complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003712 transcription cofactor activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008233 peptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0017111 nucleoside-triphosphatase activity molecular_function
GO:0031531 thyrotropin-releasing hormone receptor binding molecular_function