p21 protein (Cdc42/Rac)-activated kinase 6
Symbol
PAK6
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| pak-2 | Caenorhabditis elegans | |
| pak6 | Danio rerio | |
| Pak6 | Mus musculus | |
| Pak6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0007010 | cytoskeleton organization | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004672 | protein kinase activity | molecular_function | |
| GO:0004674 | protein serine/threonine kinase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |