mitogen-activated protein kinase kinase 1

Symbol

MAP2K1 (may also be known as: MEK1, MAPK)

Organism

Human

Orthologs

SymbolSpecies
mek-2 Caenorhabditis elegans
map2k1 Danio rerio
Map2k1 Mus musculus
Map2k1 Rattus norvegicus
byr1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA130 mitogen-activated protein kinase kinase 1 Molecular brain Human MAP2K1 7.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0000186 activation of MAPKK activity biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0003056 regulation of vascular smooth muscle contraction biological_process
GO:0006928 cellular component movement biological_process
GO:0006935 chemotaxis biological_process
GO:0006979 response to oxidative stress biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007067 mitosis biological_process
GO:0007165 signal transduction biological_process
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0007265 Ras protein signal transduction biological_process
GO:0007411 axon guidance biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0030182 neuron differentiation biological_process
GO:0030216 keratinocyte differentiation biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0032320 positive regulation of Ras GTPase activity biological_process
GO:0032402 melanosome transport biological_process
GO:0032872 regulation of stress-activated MAPK cascade biological_process
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter biological_process
GO:0034111 negative regulation of homotypic cell-cell adhesion biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0045087 innate immune response biological_process
GO:0045597 positive regulation of cell differentiation biological_process
GO:0046579 positive regulation of Ras protein signal transduction biological_process
GO:0047496 vesicle transport along microtubule biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048678 response to axon injury biological_process
GO:0048812 neuron projection morphogenesis biological_process
GO:0048870 cell motility biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0060674 placenta blood vessel development biological_process
GO:0060711 labyrinthine layer development biological_process
GO:0090170 regulation of Golgi inheritance biological_process
GO:0090398 cellular senescence biological_process
GO:2000641 regulation of early endosome to late endosome transport biological_process
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005769 early endosome cellular_component
GO:0005770 late endosome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005816 spindle pole body cellular_component
GO:0005829 cytosol cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005874 microtubule cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005925 focal adhesion cellular_component
GO:0005938 cell cortex cellular_component
GO:0032839 dendrite cytoplasm cellular_component
GO:0033267 axon part cellular_component
GO:0043204 perikaryon cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004708 MAP kinase kinase activity molecular_function
GO:0004712 protein serine/threonine/tyrosine kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004728 receptor signaling protein tyrosine phosphatase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0017016 Ras GTPase binding molecular_function
GO:0031435 mitogen-activated protein kinase kinase kinase binding molecular_function