fatty acyl CoA reductase 2

Symbol

FAR2 (may also be known as: None)

Organism

Human

Description

This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

Orthologs

SymbolSpecies
fard-1 Caenorhabditis elegans
CG5065 Drosophila melanogaster
Far2 Mus musculus
Far2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3957 Gene expression of FAR2 decreases with age Molecular skin Human FAR2 —

GO Terms

GO IDGO TermGO Category
GO:0008610 lipid biosynthetic process biological_process
GO:0008611 ether lipid biosynthetic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005777 peroxisome cellular_component
GO:0005778 peroxisomal membrane cellular_component
GO:0005782 peroxisomal matrix cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function