protein kinase, AMP-activated, alpha 1 catalytic subunit

Symbol

PRKAA1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3340 Gene expression of PRKAA1 increases with age Molecular skin Human PRKAA1 —

GO Terms

GO IDGO TermGO Category
GO:0000187 activation of MAPK activity biological_process
GO:0001666 response to hypoxia biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006633 fatty acid biosynthetic process biological_process
GO:0006950 response to stress biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007165 signal transduction biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0008610 lipid biosynthetic process biological_process
GO:0010508 positive regulation of autophagy biological_process
GO:0016055 Wnt receptor signaling pathway biological_process
GO:0016568 chromatin modification biological_process
GO:0031669 cellular response to nutrient levels biological_process
GO:0032007 negative regulation of TOR signaling cascade biological_process
GO:0035404 histone-serine phosphorylation biological_process
GO:0042149 cellular response to glucose starvation biological_process
GO:0042593 glucose homeostasis biological_process
GO:0042752 regulation of circadian rhythm biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0045542 positive regulation of cholesterol biosynthetic process biological_process
GO:0045768 positive regulation of anti-apoptosis biological_process
GO:0045821 positive regulation of glycolysis biological_process
GO:0046318 negative regulation of glucosylceramide biosynthetic process biological_process
GO:0046320 regulation of fatty acid oxidation biological_process
GO:0048511 rhythmic process biological_process
GO:0050995 negative regulation of lipid catabolic process biological_process
GO:0055089 fatty acid homeostasis biological_process
GO:2000505 regulation of energy homeostasis biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0031588 AMP-activated protein kinase complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004679 AMP-activated protein kinase activity molecular_function
GO:0004691 cAMP-dependent protein kinase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0035174 histone serine kinase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050321 tau-protein kinase activity molecular_function