plexin A3

Symbol

PLXNA3 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

Orthologs

SymbolSpecies
plx-1 Caenorhabditis elegans
plexA Drosophila melanogaster
plxna3 Danio rerio
Plxna3 Mus musculus
Plxna3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2906 Gene expression of PLXNA3 decreases with age Molecular adipose tissue Human PLXNA3 —

GO Terms

GO IDGO TermGO Category
GO:0007165 signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007411 axon guidance biological_process
GO:0021766 hippocampus development biological_process
GO:0021860 pyramidal neuron development biological_process
GO:0048843 negative regulation of axon extension involved in axon guidance biological_process
GO:0050919 negative chemotaxis biological_process
GO:0051495 positive regulation of cytoskeleton organization biological_process
GO:0071526 semaphorin-plexin signaling pathway biological_process
GO:0002116 semaphorin receptor complex cellular_component
GO:0005622 intracellular cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0017154 semaphorin receptor activity molecular_function