tumor necrosis factor receptor superfamily, member 19
Symbol
TNFRSF19
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| tnfrsf19 | Danio rerio | |
| Tnfrsf19 | Mus musculus | |
| Tnfrsf19 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001942 | hair follicle development | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0006917 | induction of apoptosis | biological_process | |
| GO:0007254 | JNK cascade | biological_process | |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | biological_process | |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_process | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0005031 | tumor necrosis factor-activated receptor activity | molecular_function | |
| GO:0005488 | binding | molecular_function | |