synaptotagmin-like 2

Symbol

SYTL2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]

Orthologs

SymbolSpecies
LOC563188 Danio rerio
Sytl2 Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3907 Gene expression of SYTL2 increases with age Molecular skin Human SYTL2 —

GO Terms

GO IDGO TermGO Category
GO:0006886 intracellular protein transport biological_process
GO:0006887 exocytosis biological_process
GO:0006904 vesicle docking involved in exocytosis biological_process
GO:0010923 negative regulation of phosphatase activity biological_process
GO:0016192 vesicle-mediated transport biological_process
GO:0070257 positive regulation of mucus secretion biological_process
GO:0005624 membrane fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0008021 synaptic vesicle cellular_component
GO:0016020 membrane cellular_component
GO:0019897 extrinsic to plasma membrane cellular_component
GO:0042470 melanosome cellular_component
GO:0070382 exocytic vesicle cellular_component
GO:0001786 phosphatidylserine binding molecular_function
GO:0005215 transporter activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding molecular_function
GO:0017137 Rab GTPase binding molecular_function
GO:0019902 phosphatase binding molecular_function
GO:0042043 neurexin family protein binding molecular_function