cathepsin A

Symbol

CTSA (may also be known as: None)

Organism

Human

Description

This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
F13D12.6 Caenorhabditis elegans
LOC792966 Danio rerio
Ctsa Mus musculus
Ctsa Rattus norvegicus
PRC1 Saccharomyces cerevisiae
kex1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3333 Gene expression of CTSA decreases with age Molecular skin Human CTSA —

GO Terms

GO IDGO TermGO Category
GO:0006508 proteolysis biological_process
GO:0006665 sphingolipid metabolic process biological_process
GO:0006687 glycosphingolipid metabolic process biological_process
GO:0006886 intracellular protein transport biological_process
GO:0043085 positive regulation of catalytic activity biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005764 lysosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0043202 lysosomal lumen cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0004180 carboxypeptidase activity molecular_function
GO:0004185 serine-type carboxypeptidase activity molecular_function
GO:0008047 enzyme activator activity molecular_function
GO:0008233 peptidase activity molecular_function