XIAP associated factor 1
Symbol
XAF1
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| Xaf1 | Mus musculus | |
| XAF1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006915 | apoptotic process | biological_process | |
| GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
| GO:0060337 | type I interferon-mediated signaling pathway | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |