FEV (ETS oncogene family)


FEV (may also be known as: None)




This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]


fev Danio rerio
Fev Mus musculus
Fev Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007399 nervous system development biological_process
GO:0030154 cell differentiation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0005634 nucleus cellular_component
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function