toll interacting protein
Symbol
TOLLIP
(may also be known as: None)
Organism
Human
Description
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]
Orthologs
Symbol | Species | |
---|---|---|
tli-1 | Caenorhabditis elegans | |
tollip | Danio rerio | |
Tollip | Mus musculus | |
Tollip | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2219 | toll interacting protein decreases with age | Molecular | parietal lobe | Human | TOLLIP | 53.6% Decrease Gene Expression Level | |
DAA2218 | toll interacting protein decreases with age | Molecular | parietal lobe | Human | TOLLIP | 61.5% Decrease Gene Expression Level | |
DAA2235 | toll interacting protein decreases with age | Molecular | frontal lobe | Human | TOLLIP | 36.3% Decrease Gene Expression Level | |
DAA2233 | toll interacting protein decreases with age | Molecular | frontal lobe | Human | TOLLIP | 59.5% Decrease Gene Expression Level | |
DAA2234 | toll interacting protein decreases with age | Molecular | frontal lobe | Human | TOLLIP | 57.8% Decrease Gene Expression Level | |
DAA2220 | toll interacting protein decreases with age | Molecular | parietal lobe | Human | TOLLIP | 33.4% Decrease Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0006954 | inflammatory response | biological_process | |
GO:0007165 | signal transduction | biological_process | |
GO:0007267 | cell-cell signaling | biological_process | |
GO:0016310 | phosphorylation | biological_process | |
GO:0035556 | intracellular signal transduction | biological_process | |
GO:0045087 | innate immune response | biological_process | |
GO:0045321 | leukocyte activation | biological_process | |
GO:0005622 | intracellular | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005829 | cytosol | cellular_component | |
GO:0045092 | interleukin-18 receptor complex | cellular_component | |
GO:0045323 | interleukin-1 receptor complex | cellular_component | |
GO:0004871 | signal transducer activity | molecular_function | |
GO:0005515 | protein binding | molecular_function | |
GO:0019900 | kinase binding | molecular_function | |
GO:0035325 | Toll-like receptor binding | molecular_function | |