toll interacting protein

Symbol

TOLLIP (may also be known as: None)

Organism

Human

Description

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]

Orthologs

SymbolSpecies
tli-1 Caenorhabditis elegans
tollip Danio rerio
Tollip Mus musculus
Tollip Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2219 toll interacting protein decreases with age Molecular parietal lobe Human TOLLIP 53.6% Decrease Gene Expression Level
DAA2218 toll interacting protein decreases with age Molecular parietal lobe Human TOLLIP 61.5% Decrease Gene Expression Level
DAA2235 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 36.3% Decrease Gene Expression Level
DAA2233 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 59.5% Decrease Gene Expression Level
DAA2234 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 57.8% Decrease Gene Expression Level
DAA2220 toll interacting protein decreases with age Molecular parietal lobe Human TOLLIP 33.4% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006954 inflammatory response biological_process
GO:0007165 signal transduction biological_process
GO:0007267 cell-cell signaling biological_process
GO:0016310 phosphorylation biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0045087 innate immune response biological_process
GO:0045321 leukocyte activation biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0045092 interleukin-18 receptor complex cellular_component
GO:0045323 interleukin-1 receptor complex cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0005515 protein binding molecular_function
GO:0019900 kinase binding molecular_function
GO:0035325 Toll-like receptor binding molecular_function