polymerase (RNA) II (DNA directed) polypeptide H

Symbol

POLR2H (may also be known as: None)

Organism

Human

Description

The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Orthologs

SymbolSpecies
rpb-8 Caenorhabditis elegans
Rpb8 Drosophila melanogaster
zgc:110289 Danio rerio
Polr2h Mus musculus
LOC100912534 Rattus norvegicus
RPB8 Saccharomyces cerevisiae
rpb8 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3330 Gene expression of POLR2H increases with age Molecular skin Human POLR2H —

GO Terms

GO IDGO TermGO Category
GO:0000398 nuclear mRNA splicing, via spliceosome biological_process
GO:0006281 DNA repair biological_process
GO:0006283 transcription-coupled nucleotide-excision repair biological_process
GO:0006289 nucleotide-excision repair biological_process
GO:0006351 transcription, DNA-dependent biological_process
GO:0006360 transcription from RNA polymerase I promoter biological_process
GO:0006361 transcription initiation from RNA polymerase I promoter biological_process
GO:0006362 transcription elongation from RNA polymerase I promoter biological_process
GO:0006363 termination of RNA polymerase I transcription biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006367 transcription initiation from RNA polymerase II promoter biological_process
GO:0006368 transcription elongation from RNA polymerase II promoter biological_process
GO:0006370 mRNA capping biological_process
GO:0006383 transcription from RNA polymerase III promoter biological_process
GO:0006385 transcription elongation from RNA polymerase III promoter biological_process
GO:0006386 termination of RNA polymerase III transcription biological_process
GO:0006468 protein phosphorylation biological_process
GO:0008380 RNA splicing biological_process
GO:0010467 gene expression biological_process
GO:0016032 viral reproduction biological_process
GO:0050434 positive regulation of viral transcription biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005665 DNA-directed RNA polymerase II, core complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003899 DNA-directed RNA polymerase activity molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0008270 zinc ion binding molecular_function