wingless-type MMTV integration site family, member 4

Symbol

WNT4 (may also be known as: None)

Organism

Human

Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
wg Drosophila melanogaster
wnt4a Danio rerio
Wnt4 Mus musculus
Wnt4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3891 Gene expression of WNT4 increases with age Molecular skin Human WNT4 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1338 wingless-related MMTV integration site 4 Molecular hematological system Mouse Wnt4 44.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001656 metanephros development biological_process
GO:0001658 branching involved in ureteric bud morphogenesis biological_process
GO:0001822 kidney development biological_process
GO:0001823 mesonephros development biological_process
GO:0001837 epithelial to mesenchymal transition biological_process
GO:0001838 embryonic epithelial tube formation biological_process
GO:0001889 liver development biological_process
GO:0006702 androgen biosynthetic process biological_process
GO:0007165 signal transduction biological_process
GO:0007267 cell-cell signaling biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007276 gamete generation biological_process
GO:0007492 endoderm development biological_process
GO:0007548 sex differentiation biological_process
GO:0008584 male gonad development biological_process
GO:0008585 female gonad development biological_process
GO:0009798 axis specification biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0010894 negative regulation of steroid biosynthetic process biological_process
GO:0016055 Wnt receptor signaling pathway biological_process
GO:0018345 protein palmitoylation biological_process
GO:0022407 regulation of cell-cell adhesion biological_process
GO:0030237 female sex determination biological_process
GO:0030325 adrenal gland development biological_process
GO:0030501 positive regulation of bone mineralization biological_process
GO:0032349 positive regulation of aldosterone biosynthetic process biological_process
GO:0032967 positive regulation of collagen biosynthetic process biological_process
GO:0033077 T cell differentiation in thymus biological_process
GO:0033080 immature T cell proliferation in thymus biological_process
GO:0035567 non-canonical Wnt receptor signaling pathway biological_process
GO:0038030 non-canonical Wnt receptor signaling pathway via MAPKKK cascade biological_process
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway biological_process
GO:0042445 hormone metabolic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0045165 cell fate commitment biological_process
GO:0045596 negative regulation of cell differentiation biological_process
GO:0045669 positive regulation of osteoblast differentiation biological_process
GO:0045836 positive regulation of meiosis biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0048599 oocyte development biological_process
GO:0051145 smooth muscle cell differentiation biological_process
GO:0060070 canonical Wnt receptor signaling pathway biological_process
GO:0060126 somatotropin secreting cell differentiation biological_process
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation biological_process
GO:0060231 mesenchymal to epithelial transition biological_process
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis biological_process
GO:0061180 mammary gland epithelium development biological_process
GO:0061184 positive regulation of dermatome development biological_process
GO:0061205 paramesonephric duct development biological_process
GO:0061369 negative regulation of testicular blood vessel morphogenesis biological_process
GO:0071392 cellular response to estradiol stimulus biological_process
GO:0071464 cellular response to hydrostatic pressure biological_process
GO:0071560 cellular response to transforming growth factor beta stimulus biological_process
GO:0072033 renal vesicle formation biological_process
GO:0072034 renal vesicle induction biological_process
GO:0072162 metanephric mesenchymal cell differentiation biological_process
GO:0072164 mesonephric tubule development biological_process
GO:0072273 metanephric nephron morphogenesis biological_process
GO:0090002 establishment of protein localization in plasma membrane biological_process
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway biological_process
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway biological_process
GO:2000019 negative regulation of male gonad development biological_process
GO:2000066 positive regulation of cortisol biosynthetic process biological_process
GO:2000225 negative regulation of testosterone biosynthetic process biological_process
GO:0005576 extracellular region cellular_component
GO:0005578 proteinaceous extracellular matrix cellular_component
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0001664 G-protein coupled receptor binding molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0005109 frizzled binding molecular_function
GO:0005201 extracellular matrix structural constituent molecular_function
GO:0048018 receptor agonist activity molecular_function