paired related homeobox 1

Symbol

PRRX1 (may also be known as: None)

Organism

Human

Description

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
prrx1a Danio rerio
Prrx1 Mus musculus
Prrx1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3328 Gene expression of PRRX1 decreases with age Molecular skin Human PRRX1 —

GO Terms

GO IDGO TermGO Category
GO:0007275 multicellular organismal development biological_process
GO:0005634 nucleus cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function