pantothenate kinase 1

Symbol

PANK1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]

Orthologs

SymbolSpecies
pank1a Danio rerio
Pank1 Mus musculus
Pank1 Rattus norvegicus
CAB1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3884 Gene expression of PANK1 decreases with age Molecular skin Human PANK1 —

GO Terms

GO IDGO TermGO Category
GO:0006766 vitamin metabolic process biological_process
GO:0006767 water-soluble vitamin metabolic process biological_process
GO:0009108 coenzyme biosynthetic process biological_process
GO:0015937 coenzyme A biosynthetic process biological_process
GO:0015939 pantothenate metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004594 pantothenate kinase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016740 transferase activity molecular_function