AT rich interactive domain 4B (RBP1-like)
Symbol
ARID4B
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG34422 | Drosophila melanogaster | |
| ch1073-321c8.1 | Danio rerio | |
| Arid4b | Mus musculus | |
| Arid4b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0008150 | biological_process | biological_process | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0003674 | molecular_function | molecular_function | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |