acyl-CoA synthetase long-chain family member 5
Symbol
ACSL5
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| acs-13 | Caenorhabditis elegans | |
| acsl5 | Danio rerio | |
| Acsl5 | Mus musculus | |
| Acsl5 | Rattus norvegicus | |
| FAA2 | Saccharomyces cerevisiae |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006631 | fatty acid metabolic process | biological_process | |
| GO:0007584 | response to nutrient | biological_process | |
| GO:0009744 | response to sucrose stimulus | biological_process | |
| GO:0009749 | response to glucose stimulus | biological_process | |
| GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport | biological_process | |
| GO:0010867 | positive regulation of triglyceride biosynthetic process | biological_process | |
| GO:0015908 | fatty acid transport | biological_process | |
| GO:0019432 | triglyceride biosynthetic process | biological_process | |
| GO:0032869 | cellular response to insulin stimulus | biological_process | |
| GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process | biological_process | |
| GO:0044255 | cellular lipid metabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0070723 | response to cholesterol | biological_process | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005741 | mitochondrial outer membrane | cellular_component | |
| GO:0005743 | mitochondrial inner membrane | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004467 | long-chain fatty acid-CoA ligase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016874 | ligase activity | molecular_function | |