platelet-derived growth factor receptor-like

Symbol

PDGFRL (may also be known as: None)

Organism

Human

Description

This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
pdgfrl Danio rerio
Pdgfrl Mus musculus
Pdgfrl Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3315 Gene expression of PDGFRL decreases with age Molecular skin Human PDGFRL —

GO Terms

GO IDGO TermGO Category
GO:0008150 biological_process biological_process
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway biological_process
GO:0005575 cellular_component cellular_component
GO:0005576 extracellular region cellular_component
GO:0004992 platelet activating factor receptor activity molecular_function
GO:0005019 platelet-derived growth factor beta-receptor activity molecular_function