phosphodiesterase 1B, calmodulin-dependent
Symbol
PDE1B
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2822 | Gene expression of PDE1B decreases with age | Molecular | adipose tissue | Human | PDE1B | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001505 | regulation of neurotransmitter levels | biological_process | |
| GO:0001975 | response to amphetamine | biological_process | |
| GO:0006198 | cAMP catabolic process | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007173 | epidermal growth factor receptor signaling pathway | biological_process | |
| GO:0007202 | activation of phospholipase C activity | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0007626 | locomotory behavior | biological_process | |
| GO:0008542 | visual learning | biological_process | |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | biological_process | |
| GO:0030224 | monocyte differentiation | biological_process | |
| GO:0036006 | cellular response to macrophage colony-stimulating factor stimulus | biological_process | |
| GO:0042053 | regulation of dopamine metabolic process | biological_process | |
| GO:0042428 | serotonin metabolic process | biological_process | |
| GO:0046069 | cGMP catabolic process | biological_process | |
| GO:0048011 | nerve growth factor receptor signaling pathway | biological_process | |
| GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0043025 | neuronal cell body | cellular_component | |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | molecular_function | |
| GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | molecular_function | |
| GO:0005516 | calmodulin binding | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity | molecular_function | |