phosphodiesterase 4B, cAMP-specific
Symbol
PDE4B
(may also be known as: None)
Organism
Human
Description
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2821 | Gene expression of PDE4B increases with age | Molecular | adipose tissue | Human | PDE4B | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006198 | cAMP catabolic process | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005626 | insoluble fraction | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | molecular_function | |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | molecular_function | |
| GO:0008081 | phosphoric diester hydrolase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |