ubiquitin protein ligase E3 component n-recognin 5
Symbol
UBR5
(may also be known as: None)
Organism
Human
Description
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CELE_F36A2.13 | Caenorhabditis elegans | |
| hyd | Drosophila melanogaster | |
| ubr5 | Danio rerio | |
| Ubr5 | Mus musculus | |
| Ubr5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | biological_process | |
| GO:0006464 | protein modification process | biological_process | |
| GO:0006511 | ubiquitin-dependent protein catabolic process | biological_process | |
| GO:0006974 | response to DNA damage stimulus | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0016567 | protein ubiquitination | biological_process | |
| GO:0033160 | positive regulation of protein import into nucleus, translocation | biological_process | |
| GO:0035413 | positive regulation of catenin import into nucleus | biological_process | |
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | biological_process | |
| GO:0050847 | progesterone receptor signaling pathway | biological_process | |
| GO:0090263 | positive regulation of canonical Wnt receptor signaling pathway | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003723 | RNA binding | molecular_function | |
| GO:0004842 | ubiquitin-protein ligase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0016874 | ligase activity | molecular_function | |
| GO:0016881 | acid-amino acid ligase activity | molecular_function | |
| GO:0034450 | ubiquitin-ubiquitin ligase activity | molecular_function | |
| GO:0043130 | ubiquitin binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |