PHD finger protein 21A
Symbol
PHF21A
(may also be known as: None)
Organism
Human
Description
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| phf21ab | Danio rerio | |
| Phf21a | Mus musculus | |
| Phf21a | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0001967 | suckling behavior | biological_process | |
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0016568 | chromatin modification | biological_process | |
| GO:0000118 | histone deacetylase complex | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003682 | chromatin binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |