toll-like receptor 7
Symbol
TLR7
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
Orthologs
Symbol | Species | |
---|---|---|
Tlr7 | Mus musculus | |
Tlr7 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2213 | toll-like receptor 7 increases with age | Molecular | hippocampus | Human | TLR7 | 94.7% Increase Gene Expression Level | |
DAA2214 | toll-like receptor 7 increases with age | Molecular | hippocampus | Human | TLR7 | 56.5% Increase Gene Expression Level | |
DAA2229 | toll-like receptor 7 increases with age | Molecular | parietal lobe | Human | TLR7 | 38.8% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002282 | microglial cell activation involved in immune response | biological_process | |
GO:0007165 | signal transduction | biological_process | |
GO:0007252 | I-kappaB phosphorylation | biological_process | |
GO:0032722 | positive regulation of chemokine production | biological_process | |
GO:0032755 | positive regulation of interleukin-6 production | biological_process | |
GO:0032757 | positive regulation of interleukin-8 production | biological_process | |
GO:0034154 | toll-like receptor 7 signaling pathway | biological_process | |
GO:0042221 | response to chemical stimulus | biological_process | |
GO:0042346 | positive regulation of NF-kappaB import into nucleus | biological_process | |
GO:0045078 | positive regulation of interferon-gamma biosynthetic process | biological_process | |
GO:0045087 | innate immune response | biological_process | |
GO:0045356 | positive regulation of interferon-alpha biosynthetic process | biological_process | |
GO:0045359 | positive regulation of interferon-beta biosynthetic process | biological_process | |
GO:0045416 | positive regulation of interleukin-8 biosynthetic process | biological_process | |
GO:0050729 | positive regulation of inflammatory response | biological_process | |
GO:0051607 | defense response to virus | biological_process | |
GO:0052033 | pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response | biological_process | |
GO:0071260 | cellular response to mechanical stimulus | biological_process | |
GO:0005622 | intracellular | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005764 | lysosome | cellular_component | |
GO:0005768 | endosome | cellular_component | |
GO:0005783 | endoplasmic reticulum | cellular_component | |
GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0010008 | endosome membrane | cellular_component | |
GO:0016021 | integral to membrane | cellular_component | |
GO:0031410 | cytoplasmic vesicle | cellular_component | |
GO:0032009 | early phagosome | cellular_component | |
GO:0003725 | double-stranded RNA binding | molecular_function | |
GO:0003727 | single-stranded RNA binding | molecular_function | |
GO:0004872 | receptor activity | molecular_function | |
GO:0008144 | drug binding | molecular_function | |
GO:0035197 | siRNA binding | molecular_function | |