dicarbonyl/L-xylulose reductase
Symbol
DCXR
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| dhs-21 | Caenorhabditis elegans | |
| CG7322 | Drosophila melanogaster | |
| dcxr | Danio rerio | |
| Dcxr | Mus musculus | |
| Dcxr | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | biological_process | |
| GO:0005997 | xylulose metabolic process | biological_process | |
| GO:0006006 | glucose metabolic process | biological_process | |
| GO:0006739 | NADP metabolic process | biological_process | |
| GO:0042732 | D-xylose metabolic process | biological_process | |
| GO:0051289 | protein homotetramerization | biological_process | |
| GO:0055114 | oxidation-reduction process | biological_process | |
| GO:0005902 | microvillus | cellular_component | |
| GO:0005903 | brush border | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | molecular_function | |
| GO:0016655 | oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor | molecular_function | |
| GO:0050038 | L-xylulose reductase (NADP+) activity | molecular_function | |