lymphoid enhancer-binding factor 1
Symbol
LEF1
(may also be known as: None)
Organism
Human
Description
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
Symbol | Species | |
---|---|---|
lef1 | Danio rerio | |
Lef1 | Mus musculus | |
Lef1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
GO:0001569 | patterning of blood vessels | biological_process | |
GO:0001649 | osteoblast differentiation | biological_process | |
GO:0001755 | neural crest cell migration | biological_process | |
GO:0001756 | somitogenesis | biological_process | |
GO:0001822 | kidney development | biological_process | |
GO:0001837 | epithelial to mesenchymal transition | biological_process | |
GO:0001944 | vasculature development | biological_process | |
GO:0002040 | sprouting angiogenesis | biological_process | |
GO:0006917 | induction of apoptosis | biological_process | |
GO:0007155 | cell adhesion | biological_process | |
GO:0007420 | brain development | biological_process | |
GO:0008284 | positive regulation of cell proliferation | biological_process | |
GO:0010226 | response to lithium ion | biological_process | |
GO:0010628 | positive regulation of gene expression | biological_process | |
GO:0010718 | positive regulation of epithelial to mesenchymal transition | biological_process | |
GO:0014070 | response to organic cyclic compound | biological_process | |
GO:0016055 | Wnt receptor signaling pathway | biological_process | |
GO:0016202 | regulation of striated muscle tissue development | biological_process | |
GO:0021542 | dentate gyrus development | biological_process | |
GO:0021854 | hypothalamus development | biological_process | |
GO:0021861 | forebrain radial glial cell differentiation | biological_process | |
GO:0021873 | forebrain neuroblast division | biological_process | |
GO:0021879 | forebrain neuron differentiation | biological_process | |
GO:0021943 | formation of radial glial scaffolds | biological_process | |
GO:0022008 | neurogenesis | biological_process | |
GO:0022407 | regulation of cell-cell adhesion | biological_process | |
GO:0022408 | negative regulation of cell-cell adhesion | biological_process | |
GO:0022409 | positive regulation of cell-cell adhesion | biological_process | |
GO:0030111 | regulation of Wnt receptor signaling pathway | biological_process | |
GO:0030223 | neutrophil differentiation | biological_process | |
GO:0030307 | positive regulation of cell growth | biological_process | |
GO:0030326 | embryonic limb morphogenesis | biological_process | |
GO:0030335 | positive regulation of cell migration | biological_process | |
GO:0030509 | BMP signaling pathway | biological_process | |
GO:0030854 | positive regulation of granulocyte differentiation | biological_process | |
GO:0030879 | mammary gland development | biological_process | |
GO:0031100 | organ regeneration | biological_process | |
GO:0032696 | negative regulation of interleukin-13 production | biological_process | |
GO:0032713 | negative regulation of interleukin-4 production | biological_process | |
GO:0032714 | negative regulation of interleukin-5 production | biological_process | |
GO:0033153 | T cell receptor V(D)J recombination | biological_process | |
GO:0042100 | B cell proliferation | biological_process | |
GO:0042475 | odontogenesis of dentin-containing tooth | biological_process | |
GO:0043066 | negative regulation of apoptotic process | biological_process | |
GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | biological_process | |
GO:0043392 | negative regulation of DNA binding | biological_process | |
GO:0043586 | tongue development | biological_process | |
GO:0043588 | skin development | biological_process | |
GO:0043923 | positive regulation by host of viral transcription | biological_process | |
GO:0043966 | histone H3 acetylation | biological_process | |
GO:0043967 | histone H4 acetylation | biological_process | |
GO:0045063 | T-helper 1 cell differentiation | biological_process | |
GO:0045843 | negative regulation of striated muscle tissue development | biological_process | |
GO:0045892 | negative regulation of transcription, DNA-dependent | biological_process | |
GO:0045893 | positive regulation of transcription, DNA-dependent | biological_process | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
GO:0046632 | alpha-beta T cell differentiation | biological_process | |
GO:0048069 | eye pigmentation | biological_process | |
GO:0048341 | paraxial mesoderm formation | biological_process | |
GO:0048468 | cell development | biological_process | |
GO:0048699 | generation of neurons | biological_process | |
GO:0048747 | muscle fiber development | biological_process | |
GO:0050909 | sensory perception of taste | biological_process | |
GO:0060021 | palate development | biological_process | |
GO:0060033 | anatomical structure regression | biological_process | |
GO:0060070 | canonical Wnt receptor signaling pathway | biological_process | |
GO:0060325 | face morphogenesis | biological_process | |
GO:0060326 | cell chemotaxis | biological_process | |
GO:0060561 | apoptosis involved in morphogenesis | biological_process | |
GO:0060710 | chorio-allantoic fusion | biological_process | |
GO:0061153 | trachea gland development | biological_process | |
GO:0071353 | cellular response to interleukin-4 | biological_process | |
GO:0071864 | positive regulation of cell proliferation in bone marrow | biological_process | |
GO:0071866 | negative regulation of apoptosis in bone marrow | biological_process | |
GO:0071895 | odontoblast differentiation | biological_process | |
GO:0071899 | negative regulation of estrogen receptor binding | biological_process | |
GO:0090068 | positive regulation of cell cycle process | biological_process | |
GO:0090090 | negative regulation of canonical Wnt receptor signaling pathway | biological_process | |
GO:0005634 | nucleus | cellular_component | |
GO:0005667 | transcription factor complex | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0032993 | protein-DNA complex | cellular_component | |
GO:0003677 | DNA binding | molecular_function | |
GO:0003682 | chromatin binding | molecular_function | |
GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
GO:0003705 | sequence-specific distal enhancer binding RNA polymerase II transcription factor activity | molecular_function | |
GO:0005515 | protein binding | molecular_function | |
GO:0008013 | beta-catenin binding | molecular_function | |
GO:0008134 | transcription factor binding | molecular_function | |
GO:0008301 | DNA binding, bending | molecular_function | |
GO:0030284 | estrogen receptor activity | molecular_function | |
GO:0030331 | estrogen receptor binding | molecular_function | |
GO:0035326 | enhancer binding | molecular_function | |
GO:0042393 | histone binding | molecular_function | |
GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | molecular_function | |
GO:0043565 | sequence-specific DNA binding | molecular_function | |
GO:0044212 | transcription regulatory region DNA binding | molecular_function | |
GO:0045295 | gamma-catenin binding | molecular_function | |
GO:0070016 | armadillo repeat domain binding | molecular_function | |
GO:0070742 | C2H2 zinc finger domain binding | molecular_function | |