secretion associated, Ras related GTPase 1B
Symbol
SAR1B
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| sar1b | Danio rerio | |
| Sar1b | Mus musculus | |
| Sar1b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | biological_process | |
| GO:0006184 | GTP catabolic process | biological_process | |
| GO:0006886 | intracellular protein transport | biological_process | |
| GO:0006888 | ER to Golgi vesicle-mediated transport | biological_process | |
| GO:0016044 | cellular membrane organization | biological_process | |
| GO:0016192 | vesicle-mediated transport | biological_process | |
| GO:0018279 | protein N-linked glycosylation via asparagine | biological_process | |
| GO:0043687 | post-translational protein modification | biological_process | |
| GO:0044267 | cellular protein metabolic process | biological_process | |
| GO:0048208 | COPII vesicle coating | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0012507 | ER to Golgi transport vesicle membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0032580 | Golgi cisterna membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003924 | GTPase activity | molecular_function | |
| GO:0005525 | GTP binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |