transcription factor B1, mitochondrial
Symbol
TFB1M
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| T03F1.7 | Caenorhabditis elegans | |
| mtTFB1 | Drosophila melanogaster | |
| tfb1m | Danio rerio | |
| Tfb1m | Mus musculus | |
| Tfb1m | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0042645 | mitochondrial nucleoid | cellular_component | |
| GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity | molecular_function | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008168 | methyltransferase activity | molecular_function | |
| GO:0016740 | transferase activity | molecular_function | |