phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Symbol
PCK2
(may also be known as: None)
Organism
Human
Description
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| Pck2 | Mus musculus | |
| Pck2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | biological_process | |
| GO:0006006 | glucose metabolic process | biological_process | |
| GO:0006094 | gluconeogenesis | biological_process | |
| GO:0006107 | oxaloacetate metabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0051384 | response to glucocorticoid stimulus | biological_process | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005759 | mitochondrial matrix | cellular_component | |
| GO:0004611 | phosphoenolpyruvate carboxykinase activity | molecular_function | |
| GO:0004613 | phosphoenolpyruvate carboxykinase (GTP) activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005525 | GTP binding | molecular_function | |
| GO:0016301 | kinase activity | molecular_function | |
| GO:0016829 | lyase activity | molecular_function | |
| GO:0017076 | purine nucleotide binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |