fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Symbol
FIS1
(may also be known as: None)
Organism
Human
Description
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| fis-2 | Caenorhabditis elegans | |
| Fis1 | Drosophila melanogaster | |
| uncharacterized_E9QG | Danio rerio | |
| Fis1 | Mus musculus | |
| Fis1 | Rattus norvegicus | |
| FIS1 | Saccharomyces cerevisiae | |
| fis1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000266 | mitochondrial fission | biological_process | |
| GO:0000422 | mitochondrion degradation | biological_process | |
| GO:0001836 | release of cytochrome c from mitochondria | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0007204 | elevation of cytosolic calcium ion concentration | biological_process | |
| GO:0016559 | peroxisome fission | biological_process | |
| GO:0032471 | reduction of endoplasmic reticulum calcium ion concentration | biological_process | |
| GO:0035584 | calcium-mediated signaling using intracellular calcium source | biological_process | |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | biological_process | |
| GO:0043653 | mitochondrial fragmentation involved in apoptosis | biological_process | |
| GO:0051561 | elevation of mitochondrial calcium ion concentration | biological_process | |
| GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | biological_process | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005741 | mitochondrial outer membrane | cellular_component | |
| GO:0005777 | peroxisome | cellular_component | |
| GO:0005778 | peroxisomal membrane | cellular_component | |
| GO:0005779 | integral to peroxisomal membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031307 | integral to mitochondrial outer membrane | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |