purinergic receptor P2X, ligand-gated ion channel, 7

Symbol

P2RX7 (may also be known as: None)

Organism

Human

Description

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

Orthologs

SymbolSpecies
p2rx7 Danio rerio
P2rx7 Mus musculus
P2rx7 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3302 Gene expression of P2RX7 increases with age Molecular skin Human P2RX7 —

GO Terms

GO IDGO TermGO Category
GO:0000187 activation of MAPK activity biological_process
GO:0000902 cell morphogenesis biological_process
GO:0001845 phagolysosome assembly biological_process
GO:0001916 positive regulation of T cell mediated cytotoxicity biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0002028 regulation of sodium ion transport biological_process
GO:0006509 membrane protein ectodomain proteolysis biological_process
GO:0006649 phospholipid transfer to membrane biological_process
GO:0006811 ion transport biological_process
GO:0006812 cation transport biological_process
GO:0006816 calcium ion transport biological_process
GO:0006884 cell volume homeostasis biological_process
GO:0006900 membrane budding biological_process
GO:0006954 inflammatory response biological_process
GO:0007005 mitochondrion organization biological_process
GO:0007009 plasma membrane organization biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0009612 response to mechanical stimulus biological_process
GO:0009617 response to bacterium biological_process
GO:0010043 response to zinc ion biological_process
GO:0010467 gene expression biological_process
GO:0010524 positive regulation of calcium ion transport into cytosol biological_process
GO:0014049 positive regulation of glutamate secretion biological_process
GO:0014054 positive regulation of gamma-aminobutyric acid secretion biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0016079 synaptic vesicle exocytosis biological_process
GO:0016485 protein processing biological_process
GO:0019228 regulation of action potential in neuron biological_process
GO:0019233 sensory perception of pain biological_process
GO:0030501 positive regulation of bone mineralization biological_process
GO:0031668 cellular response to extracellular stimulus biological_process
GO:0032060 bleb assembly biological_process
GO:0032308 positive regulation of prostaglandin secretion biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032963 collagen metabolic process biological_process
GO:0033198 response to ATP biological_process
GO:0034220 ion transmembrane transport biological_process
GO:0034405 response to fluid shear stress biological_process
GO:0035590 purinergic nucleotide receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0042098 T cell proliferation biological_process
GO:0042493 response to drug biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043029 T cell homeostasis biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043085 positive regulation of catalytic activity biological_process
GO:0043132 NAD transport biological_process
GO:0043409 negative regulation of MAPKKK cascade biological_process
GO:0043410 positive regulation of MAPKKK cascade biological_process
GO:0044254 multicellular organismal protein catabolic process biological_process
GO:0045087 innate immune response biological_process
GO:0045332 phospholipid translocation biological_process
GO:0045779 negative regulation of bone resorption biological_process
GO:0045919 positive regulation of cytolysis biological_process
GO:0046513 ceramide biosynthetic process biological_process
GO:0046931 pore complex assembly biological_process
GO:0048705 skeletal system morphogenesis biological_process
GO:0048873 homeostasis of number of cells within a tissue biological_process
GO:0050715 positive regulation of cytokine secretion biological_process
GO:0050717 positive regulation of interleukin-1 alpha secretion biological_process
GO:0050718 positive regulation of interleukin-1 beta secretion biological_process
GO:0050830 defense response to Gram-positive bacterium biological_process
GO:0051209 release of sequestered calcium ion into cytosol biological_process
GO:0051259 protein oligomerization biological_process
GO:0051495 positive regulation of cytoskeleton organization biological_process
GO:0051592 response to calcium ion biological_process
GO:0051602 response to electrical stimulus biological_process
GO:0051709 regulation of killing of cells of other organism biological_process
GO:0051899 membrane depolarization biological_process
GO:0051901 positive regulation of mitochondrial depolarization biological_process
GO:0072593 reactive oxygen species metabolic process biological_process
GO:0005639 integral to nuclear inner membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0005911 cell-cell junction cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0019717 synaptosome cellular_component
GO:0031594 neuromuscular junction cellular_component
GO:0032059 bleb cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0043195 terminal button cellular_component
GO:0045121 membrane raft cellular_component
GO:0000287 magnesium ion binding molecular_function
GO:0001530 lipopolysaccharide binding molecular_function
GO:0001614 purinergic nucleotide receptor activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004931 extracellular ATP-gated cation channel activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005507 copper ion binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0015267 channel activity molecular_function
GO:0042803 protein homodimerization activity molecular_function