oxytocin/neurophysin I prepropeptide

Symbol

OXT (may also be known as: None)

Organism

Human

Description

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Orthologs

SymbolSpecies
oxt Danio rerio
Oxt Mus musculus
Oxt Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3301 Gene expression of OXT decreases with age Molecular skin Human OXT —
DAA2820 Gene expression of OXT decreases with age Molecular adipose tissue Human OXT —

GO Terms

GO IDGO TermGO Category
GO:0001975 response to amphetamine biological_process
GO:0002027 regulation of heart rate biological_process
GO:0002125 maternal aggressive behavior biological_process
GO:0006950 response to stress biological_process
GO:0007165 signal transduction biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007507 heart development biological_process
GO:0007565 female pregnancy biological_process
GO:0007613 memory biological_process
GO:0007625 grooming behavior biological_process
GO:0009744 response to sucrose stimulus biological_process
GO:0010701 positive regulation of norepinephrine secretion biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0014823 response to activity biological_process
GO:0030431 sleep biological_process
GO:0032308 positive regulation of prostaglandin secretion biological_process
GO:0032355 response to estradiol stimulus biological_process
GO:0032526 response to retinoic acid biological_process
GO:0032570 response to progesterone stimulus biological_process
GO:0034695 response to prostaglandin E stimulus biological_process
GO:0035176 social behavior biological_process
GO:0035811 negative regulation of urine volume biological_process
GO:0035815 positive regulation of renal sodium excretion biological_process
GO:0042220 response to cocaine biological_process
GO:0042538 hyperosmotic salinity response biological_process
GO:0042711 maternal behavior biological_process
GO:0042713 sperm ejaculation biological_process
GO:0042755 eating behavior biological_process
GO:0042756 drinking behavior biological_process
GO:0043434 response to peptide hormone stimulus biological_process
GO:0044058 regulation of digestive system process biological_process
GO:0045472 response to ether biological_process
GO:0045776 negative regulation of blood pressure biological_process
GO:0045777 positive regulation of blood pressure biological_process
GO:0045778 positive regulation of ossification biological_process
GO:0045925 positive regulation of female receptivity biological_process
GO:0050806 positive regulation of synaptic transmission biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051591 response to cAMP biological_process
GO:0051602 response to electrical stimulus biological_process
GO:0051930 regulation of sensory perception of pain biological_process
GO:0051965 positive regulation of synapse assembly biological_process
GO:0060179 male mating behavior biological_process
GO:0060406 positive regulation of penile erection biological_process
GO:0060450 positive regulation of hindgut contraction biological_process
GO:0060455 negative regulation of gastric acid secretion biological_process
GO:0070474 positive regulation of uterine smooth muscle contraction biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0030141 secretory granule cellular_component
GO:0043195 terminal button cellular_component
GO:0005185 neurohypophyseal hormone activity molecular_function
GO:0031855 oxytocin receptor binding molecular_function